IL1B and Alzheimer disease: In AD patients, lower cognitive test scores were observed in patients with the heterozygous IL1B rs1071676 genotype (p = 0.004), while carriers of two polymorphic KEAP1 rs1048290 alleles (p = 0.035, Figure 2b) and KEAP1 rs9676881 (p = 0.035) had higher MMSE scores (Table 4).