To elucidate the mechanism that was responsible for the induction of ferroptosis in the development of psoriasis, we detected the expression of classically ferroptotic genes related to lipid peroxidation signaling pathways involving GPX4, nuclear factor erythroid 2-like 2 (NRF2), acyl–coenzyme A synthetase long-chain family member 4 (ACSL4), apoptosis-inducing factor mitochondria-associated 2 (AIFM2/FSP1), and system xc (SLC7A11/SLC3A2). This evidence concerns the gene GPX4 and psoriasis.