NPY and metabolic syndrome: Similarly, in obese and metabolic syndrome-affected adolescents, one year of combined diet + exercise (aerobic + resistance exercise) procured a significant decrease in fat mass, NPY levels (0.94 CI [0.43–2.25] vs. 1.19 CI [0.55–2.3]) and AgRP/NPY ratio (0.71 CI [0.36–1.77] 0.57 CI [0.27–1.86]) [64].