The high-grade prostatic intraepithelial neoplasia lesions can be associated with markers of transformation, such as the overexpression of the enzyme alphamethylacyl-CoA racemase (AMACR), which is associated with adenocarcinoma, the loss of the basal markers p63 (TP63), cytokeratin 5 (KRT5), and cytokeratin 14 (KRT14), and the gain of luminal markers, such as cytokeratin 8 (KRT8), while the TMPRSS2 gene is thought to be involved in luminal differentiation [15,16,21]. The gene discussed is KRT8; the disease is prostate intraepithelial neoplasia.