Genes involved in repairing DNA errors and breaks are also implicated in prostate cancer; in fact, men with BRCA1 or BRCA2 mutations have a higher probability of getting prostate cancer with a high incidence of disease aggression due to the additional activation of MYC in combination with inactivation of TP53 and PTEN [29,30]. The gene discussed is BRCA1; the disease is Familial prostate cancer.