Figure 4A shows that the plasma levels of ET-1 in MetS+Nx rats receiving the normal Mg 0.1% were increased by 170% as compared to controls. Nonetheless, no elevation in ET-1 was observed in MetS+Nx rats receiving Mg 0.6%. In addition, NO levels were slightly, but significantly reduced in the MetS+Nx+Mg0.1% group as compared to controls (Figure 4B), while in the MetS+Nx+Mg0.6% group NO levels were not different than the controls and MetS+Nx+Mg0.1% rats. This evidence concerns the gene EDN1 and metabolic syndrome.