GPX8 and metabolic dysfunction-associated steatotic liver disease: In a large-scale study with human subjects, the serum expression of miR-193a-5p correlated with the hepatic expression of the antioxidant enzyme GPX8 in NAFLD patients, whereas lipid overload induced the downregulation of this miRNA, thus suggesting a regulatory mechanism involving this miRNA and antioxidant defenses in NAFLD [94].