TH and Parkinson disease: In detail, 1 was assessed recording the expression of tyrosine hydroxylase (TH), the rate-limiting step enzyme in the biosynthesis of dopamine, in the striatum and substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson’s disease model mice and behavioral changes after injection of the same auraptene.