Furthermore, in comparison to the Control group, the genes of the natriuretic peptide A (Nppa), protein Kinase C beta (Prkcb), alpha (Prkca), and gamma (Prkcg) also presented elevated mRNA expression of 2.6-, 3.1-, 2.8- and 1.3-fold, respectively, in PAE group. Here, NPPA is linked to pulmonary artery enlargement.