KL and Alzheimer disease: Thus, induction of Mn-SOD through the reduced phosphorylation of FoxO proteins seems to be important in the resistance to oxidative stress and the extended longevity of the Klotho-overexpressing mice [48], for the neuroprotective effects of Klotho administration in Alzheimer’s disease mice models [94], and for the antioxidative effect of Klotho in diverse cultured cells [43,94,95].