Despite the enlightening results regarding the protective role of Klotho as an anti-aging, antioxidant, mitochondrial function-protecting, oxidative stress-reducing, antifibrotic, anti-inflammatory, autophagy-stimulating, and stemness of progenitor cells-preserving molecule, obtained in experimental models of premature aging associated with various pathologies, and in particular kidney disease, it is necessary to design clinical trials in order to transfer the results obtained from experimental models to clinical practice and to be able to analyze its potential efficacy in kidney protection. The gene discussed is KL; the disease is kidney disorder.