Similarly, Klotho gene delivery attenuates the progression of hypertension and kidney damage in spontaneous hypertensive rats [144,145], and ameliorates angiotensin II-induced kidney injury [146], improves endothelial function [147], and protects from uremic cardiomyopathy in heterozygous Klotho-deficient CKD mice [148]. Here, KL is linked to hypertensive disorder.