HMOX1 and type 2 diabetes mellitus: Moreover, we observed a tendency for an increase in GST (p = 0.0792) and a significant increase in HO-1 (p < 0.05), GCLc (p < 0.01) and GCLm (p < 0.05) mRNA levels in PBMCs from T2D-PDT patients in comparison to PDT (Figure 4A).