Interestingly, the CD3+CD8+ lymphocytes subpopulation presented similar results to those observed in PBMCs with respect to reduced SOD1 and GST mRNA levels in PDT; however, decreased levels of SOD1 and GST mRNA levels were also observed in T2D-PDT patients CD3+CD8+ lymphocytes, in comparison to control individuals. Here, SOD1 is linked to type 2 diabetes mellitus.