GAL and major depressive disorder: On the basis of the findings of this study, a subsequent study using the FST rat model of depression revealed that the intra-DRN injection of galanin and a GAL2 agonist (AR-M1896) resulted in an antidepressant effect during the forced swim test, whereas the intra-DRN administration of a GAL1 agonist (M617) had no effect.