In addition to alleviation of Aβ-induced cognitive impairment, other groups found that MSC-derived exosomes promoted neurogenesis in the subventricular zone [72] and attenuated neuroinflammation in drug (streptozotocin)-induced AD mice [73], double transgenic (APP/PS1) AD [69,74,75], and triple (APP Swedish, MAPT P301L, and PSEN1 M146V) transgenic AD [68] mouse models. This evidence concerns the gene PSEN1 and Alzheimer disease.