The observation of AD-like traits both with behaviour patterns of memory deficits, loss of neurons in cortex and hippocampal area, amyloid plaques and mechanistically in terms of upregulation of GSK-3β and Dkk1 similar to the classic Aβ induced AD model, gives a promising lead to the effect of Wnt antagonism in AD-like neurodegeneration. The gene discussed is GSK3B; the disease is Alzheimer disease.