To analyze the effect of Wnt inhibition in neurodegeneration in vivo, another model was created by injecting a proprietary Wnt antagonist AD201, a protein belonging to the secreted frizzled related protein (sFRP) family in a similar manner and compared with the well-characterized Aβ-AD model for AD-associated behavioural and pathological changes. This evidence concerns the gene FRZB and Alzheimer disease.