Furthermore, this study explored the potential target proteins of BMCE by 2D liquid chromatography–mass spectrometry, including the downregulation of inflammation-related proteins (kallikrein 1-related peptidase and Calreticulin), Sjogren’s syndrome biomarker (Sjogren’s syndrome antigen B), apoptosis-related proteins (Caspase-8, CASP8-associated protein 2, and caspase recruitment domain protein 12), and the up-regulation of stem cell and development proteins (Nestin and Vimentin) and salivary gland biology markers (a-amylase, aquaporin 1 (AQP1), AQP5, parotid secretory protein (PSP). The gene discussed is BPIFA2; the disease is Sjogren syndrome.