Interestingly, our investigations showed that ASH did not significantly change Bax, Bcl2, Bcl-XL and Mcl-1 expression, while it decreased the mitochondrial membrane potential, increased ROS, activated caspase-3/-7 and induced apoptosis in GBM cell lines (U87 and U251). This evidence concerns the gene BCL2L1 and glioblastoma.