Recently, the knockdown of Mgrn1 in a mouse melanoma cell line, which encodes mahogunin ring finger 1 (MGRN1), a RING-finger nuclear-cytoplasmic E3-ubiquitin ligase ubiquitously expressed in mammals, was associated with increased TYR specific activity and pigment production due to the neutralization of melanosomal pH, through the induction of the Ca2+ transporter mucolipin transient receptor potential cation channel 3 (MCOLN3) expression, also termed TRPML3 [228]. The gene discussed is MCOLN3; the disease is melanoma.