One patient died as a result of respiratory failure, and investigators demonstrated that mesothelin was upregulated in areas of inflammation and fibrosis within the lung, suggesting that on-target off-tumour toxicity was responsible for this event (https://www.med.upenn.edu/cellicon2021/assets/user-content/documents/tanyi.pdf, accessed on 15 December 2022). This evidence concerns the gene MSLN and neoplasm.