cDCs and moDCs obtained from SSc patients were shown to secrete high levels of IL-6 and tumor necrosis factor (TNF)-α upon TLR2, TLR3, and TLR4 stimulation, with TLR2 and TLR4 activation also inducing high quantities of IL-10 [55]. The gene discussed is TLR2; the disease is systemic sclerosis.