Osteopontin, Galectin-1, Mesothelin, and VEGF are higher in mesothelioma. 15 surface proteins (CD9, CD63, CD81, CD2, CD8, CD14, CD29, CD44, CD49e, CD62p, CD105, CD146, CD326, HLA-ABC, and MCSP) were higher in adenocarcinoma. Angiopoietin-1 higher in benign samples. Here, SPP1 is linked to adenocarcinoma.