Spectroscopy of lysed RBCs pre-incubated with CT drugs showed that after 3–4 h of exposure there is an increase in the formation of reversible metHb (Hb(FeIII)) and nonreversible hemichrome (Hb(FeIV)) (Figure A2), which may also contribute to anemia during chemotherapy. The gene discussed is GSTM1; the disease is anemia.