It was previously reported that SEVs can carry cancer-cell-specific proteins and enter saliva from the blood in patients with lung cancer [19], and brain-derived EVs (L1CAM+) have also been found in the saliva of people with Parkinson’s disease [23], as were amyloid-beta and p-tau markers of Alzheimer’s disease [40]. The gene discussed is L1CAM; the disease is early-onset autosomal dominant Alzheimer disease.