It is now a well-known fact that HLA-E expression has clinical relevance, and it has a high impact on tumor progression, metastasis, and the reduced survival of patients with some tumors, e.g., in laryngeal [147], mammary [131], non-small-cell lung [148], ovarian [149], and colorectal carcinomas [150,151]. The gene discussed is HLA-E; the disease is neoplasm.