So, while we can control the progression of the liver-damaging process by monitoring BUB1B and RRM2 gene expression and preventing the progression of reversible liver fibrosis to irreversible liver cancer as a result of AFB1 exposure, we still need to understand the functional roles and potential mechanisms of BUB1B and RRM2 in liver fibrosis and liver cancer progression as a result of AFB1 exposure. This evidence concerns the gene RRM2 and liver cancer.