So, while we can control the progression of the liver-damaging process by monitoring BUB1B and RRM2 gene expression and preventing the progression of reversible liver fibrosis to irreversible liver cancer as a result of AFB1 exposure, we still need to understand the functional roles and potential mechanisms of BUB1B and RRM2 in liver fibrosis and liver cancer progression as a result of AFB1 exposure. The gene discussed is BUB1B; the disease is Hepatic fibrosis.