In human osteosarcoma U2-OS and cervical cancer HeLa cell lines, TMBIM4 is considered a novel regulator of focal adhesion dynamics, cell adhesion, and migration by activating store-operated Ca2+ entry, thereby stimulating calpain 2 activity to increase the cleavage of focal adhesion proteins [21]. The gene discussed is TMBIM4; the disease is osteosarcoma.