Interestingly, during the development of melanoma, where Cx43 is lost in malignant cells, Cx43, Cx26 and Cx30 expression was reported to be enhanced in the surrounding normal epidermis and correlated with the grade of the tumor, while this was not observed in benign nevi, as shown by measuring the mRNA content [130] and the evaluation of the protein localized at the membrane [131]. This evidence concerns the gene GJA1 and melanoma.