Furthermore, we observe the deregulation of multiple major cellular signaling pathways such as subnetwork #15 (Apoptosis, Apoptosis modulation and signaling, Hippo-Merlin signaling dysregulation), subnetwork #14 (PI3K/Akt signaling pathway, Therapy-induced HIF1 survival signaling, Mesothelioma), and subnetwork #11 (Notch signaling, MAPK signaling pathway, Canonical and noncanonical Notch signaling). This evidence concerns the gene AKT1 and mesothelioma.