In addition, Burberry et al. demonstrated the fundamental role of C9orf72 in modulating the inflammatory response of the vagus nerve triggered by the GM alterations to the CNS X. C9orf72 is the most common genetic variant that contributes to ALS., Specifically, C9orf72 prevents the microbiota from inducing a pathological inflammatory response. This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.