Multiple risk prediction models based on clinical factors such as age, sex, albumin, bilirubin, HBV DNA, ALT, HBeAg, alcohol history and liver stiffness for HBV-related HCC have also been proposed [10] but have limited predictive values (AUCs of 0.72–0.82 and 0.72–0.75) for the prediction of the development of HCC at 3 years and 5 years, respectively [11]. This evidence concerns the gene ALB and hepatocellular carcinoma.