It is known that fibrotic pancreatic tissue develops as a result of activation of pancreatic stellate cells and subsequent deposit of extracellular matrix and is observed in both pancreatic cancer and pancreatitis [26], and in mice it was shown that Carbohydrate Antigen (CA) 19-9 induced not only pancreatic cancer but also pancreatitis by activation of epidermal growth factor [27], which is also known to regulate pancreatic fibrosis [28]. Here, EGF is linked to familial pancreatic carcinoma.