IL18 and acute respiratory distress syndrome: Particularly, the release of IL-1β and IL-18 stimulates the activation of innate immune cells and the overproduction of other inflammatory cytokines, such as IL-6, TNFα, IL-8 and IL-10, paving the way to the harmful cytokine release syndrome, the basis for the development of acute respiratory distress syndrome (ARDS), multiorgan failure and coagulopathy [21,23].