Moreover, our previous study revealed that ADAMTS13:AC, VWF:Ag, and VWF:Ag/ADAMTS13:AC levels gradually decreased, increased, and increased, respectively, according to the severity of LC [2,8,9], i.e., ADAMTS13:AC, VWF:Ag, and VWF:Ag/ADAMTS13:AC were associated with functional hepatic reserve, and alcohol intake decreased ADAMTS13:AC levels and increased VWF:Ag and VWF:Ag/ADAMTS13:AC levels in healthy volunteers [13]. This evidence concerns the gene RENBP and laryngotracheoesophageal cleft.