Our previous study reported that Et levels in patients with LC increased according to the severity of LC [12,36], and a high Et level is a predictive biomarker of the development of ACLF in patients with LC [35], and patients with LC and high Et levels had lower ADAMTS13:AC and higher VWF:Ag levels than those with low Et levels [12]. This evidence concerns the gene VWF and laryngotracheoesophageal cleft.