TNF and infection: Intravenous injection of the spring viremia of carp virus (SVCV) into the caudal vein of zebrafish larvae also leads to an IFN-dependent antiviral response supported by CRFB1 and CRFB5 [341], while an immersion-based model of SVCV infection fails to activate interferon-dependent signaling pathways but still elicits a strong pro-inflammatory response by inducing IL1β, TNFα, and lymphotoxin α (LTα) [342].