In another study, Gong et al. showed that the RIG-I-like receptor LGP2 is critical for zebrafish survival upon infection by SVCV, as it promotes a strong IFN response through upregulation of IFNφ1, IFNφ3, MXb, IRF3, and IRF7, at early stages of the infection, and then downregulates this same response at later stages, by attenuating TBK1 and IKKi, upon sensing of high levels of IFN production [346]. This evidence concerns the gene IRF3 and infection.