MAP2K7 and cancer: Just as targeting cancer cell metabolism as a strategy to identify new therapeutic approaches offers a unique opportunity for drug discovery [40], and based on the fact that valtrate interferes with the MEK/ERK signaling pathway, it may be interesting to investigate the effects of valtrate on GBM cell metabolism to gain a more comprehensive understanding of the biological effects of valtrate, such as inducing apoptosis by interfering with the Warburg effect or disrupting temozolomide resistance, to prevent GBM recurrence.