Just as targeting cancer cell metabolism as a strategy to identify new therapeutic approaches offers a unique opportunity for drug discovery [40], and based on the fact that valtrate interferes with the MEK/ERK signaling pathway, it may be interesting to investigate the effects of valtrate on GBM cell metabolism to gain a more comprehensive understanding of the biological effects of valtrate, such as inducing apoptosis by interfering with the Warburg effect or disrupting temozolomide resistance, to prevent GBM recurrence. The gene discussed is MAP2K7; the disease is glioblastoma.