TNF and Autoimmunity: In terms of the potential consequences of intragenomic rearrangements involving ORF7b of SARS-CoV-2, the function of the SARS-CoV-2 ORF7b protein remains to be determined and has been suggested to mediate tumor necrosis factor-α-induced apoptosis based on cell culture data [90] and theoretically the dysfunction of olfactory receptors by triggering autoimmunity [91].