Among these proteins, KRT19, TOP2B, AREG, HGF, CKAP4, ITGB6, and NCF2 had a higher expression (> twofold) in plasma samples of severe compared to moderate COVID-19 patients, whereas CLEC4C and LTA were among the few proteins that were expressed at lower levels in severe patients. The gene discussed is TOP2B; the disease is COVID-19.