Besides Keap1, glycogen synthase kinase 3 beta (GSK3β) is another regulator of Nrf2 that acts via a Keap1-independent pathway, and activates β-transducin repeat-containing protein (β-TrCP) by ubiquitination and translocates it into the nucleus to degrade Nrf2 by phosphorylation of serine residues in the Neh6 domain [24]. However, whether hUC-MSCs transplantation along with curcumin treatment can suppress inflammation through the GSK3β/β-TrCP/Nrf2 pathway in AIS is still unclear. Here, KEAP1 is linked to androgen insensitivity syndrome.