What is more, we also discovered that the levels of serum 25(OH)VD and T-VDR expression were negatively correlated with the duration of DFU, the severity of foot ulcer, the recurrence rate of foot ulcer, the detection rate of drug-resistant bacteria in the wound and the amputation rate of simple foot ulcers or foot ulcers combined with osteomyelitis. This evidence concerns the gene VDR and osteomyelitis.