To evaluate the role of CMTM7 in vivo, the CMTM7-overexpressed MCF-7 cells were in situ injected or intravenously injected into SCID mice, which results showed that CMTM7 inhibited tumor growth (Fig. 3K) and metastasis (Fig. 3L). The gene discussed is CMTM7; the disease is neoplasm.