SALL4 and Holt-Oram syndrome: SALL4-related disorders show autosomal dominant inheritance pattern, so that haploinsufficiency of SALL4 gene leads to Duane-radial ray (DRR), IVIC, Acro-renal ocular (ARO), and rarely, Holt-oram syndromes with approximately 40–50% of cases being caused by a de novo mutations [8, 9].