Among patients diagnosed with ROP, 25 patients (44 eyes; 27.7% of total) developed spontaneous regression of the disease and 14 of them required treatment (28 eyes; 15.6% of total), including laser photocoagulation (n = 11; 22 eyes), anti-VEGF injection (n = 2; 4 eyes), or both methods (n = 1; 2 eyes). This evidence concerns the gene VEGFA and retinopathy of prematurity.