Prevalence studies across different countries suggest that approximately 1 per 1000 people of the general population harbor clinically and radiologically confirmed symptomatic pituitary adenomas with CD representing a fraction of about 4–6%3, whereas about 15% of surgically resected pituitary adenomas are functional ACTH staining adenomas2,4. The gene discussed is POMC; the disease is pituitary gland adenoma.