To this end, we first examined the differential expression between normal glandular YFP + EpCAM+ and glandular tumor YFP + EpCAM+ organoids (Fig. S3A) and found an elevation of Agr2 in tumor organoids, a protein in the TP53 pathway that has previously been shown to be expressed in human PDAC patients and is linked to tumor cell dissemination [23]. Here, AGR2 is linked to neoplasm.