Information related to data variability, correlations between variables and principal components were calculated based on log intensities of 3546 proteins that were identified across all organoid lines including YFP + EpCAM+ normal (N = 5), YFP + EpCAM+ tumor (N = 9), YFP + EpCAM- tumor (N = 9) and YFP + secondary tumor (Met; N = 8) organoids. Here, EPCAM is linked to neoplasm.