Most GISTs harbor KIT/PDGFRA mutant gene named KIT/PDGFRA mutant GIST (mu-GIST), and the remaining cases (about 10–15%) are KIT/PDGFRA wild-type GISTs (wt-GIST) which do not have mutant KIT/PDGFRA genes2. This evidence concerns the gene PDGFRA and gastrointestinal stromal tumor.