IL6ST and gastrointestinal stromal tumor: As shown in Fig. 4A, in our center, the frequently mutated genes in the wt-GIST (occurred in at least 2 cases) were neurofibromatosis type 1(NF1) (5/10), B1 v-raf murine sarcoma viral oncogene homolog B1 (BRAF) (3/10), Epidermal growth factor receptor (EGFR) (3/10), AT-Rich Interaction Domain 1B(ARID1B) (2/10), FAT Atypical Cadherin 1(FAT1) (2/10), interleukin 6 signal transducer(IL6ST) (2/10) and tuberous sclerosis2(TSC2) (2/10).