Cancer-associated fibroblasts, which can stimulate tumor progression, growth, and metastasis, are regarded as an important component of the tumor microenvironment.175 Zhou et al.172 identified three subclusters of cancer-associated fibroblasts, including COL14A1+ matrix fibroblasts, DES+COL14A1- fibroblasts, and MYL9+LUM+ fibroblasts. This evidence concerns the gene COL14A1 and neoplasm.