Moreover, we demonstrated that the abundance of CF1 was significantly correlated with the CXCL8 expression levels in independent datasets of TCGA-HNSCC (r = 0.38, P = 2.72 × 10−18), GSE41613 (r = 0.74, P = 3.41 × 10−18), GSE42743 (r = 0.62, P = 3.54 × 10−9), and GSE65858 (r = 0.68, P = 9.58 × 10−38, Fig. 5d). The gene discussed is CXCL8; the disease is head and neck squamous cell carcinoma.