Overproduction of deoxycholic acid (DCA) and lipoteichoic acid (LTA), as secondary bile acids (BAs) following HFD, due to certain species of Clostridium, led to acceleration of carcinogen-induced liver cancer progression in mice through overexpression of cyclooxygenase-2 (COX-2) (rate-limiting enzyme in the prostaglandin cascade) and stimulation of senescence in hepatic stellate cells. The gene discussed is PTGS2; the disease is liver cancer.