In another study, Clostridium species following BAs production, including murine-specific muricholic acid or lithocholic acid (LCA), caused down-regulation of chemokine (C-X-C motif) ligand 16 (CXCL16) in liver sinusoidal endothelial cells (LSECs), which contributed to diminished recruitment of natural killer T (NKT) cells to the liver, resulting in the development of tumor in diverse mouse models of primary or metastatic liver cancer [48]. This evidence concerns the gene CXCL16 and neoplasm.