Subsequent experiments in in vivo models and human samples confirmed that higher abundance of Methylobacterium associated with an exhausted phenotype in CD8+ TRM and lower numbers of infiltrating CD8+ TRM cells in the TME of gastric cancer that led to significantly reduced in expression of transforming growth factor-β (TGF-β) in the TME, implying that Methylobacterium may have a key role in gastric carcinogenesis [61]. Here, CD8A is linked to gastric cancer.