Along this line, Ma et al. reported that dietary administration of primary BAs or depletion of Clostridium by oral vancomycin augmented the expression of CXCL16 in LSECs and led to higher accumulation of IFN-γ-producing NKT cells, enrichment of CXCR6+CD62LlowCD44hi effector memory CD4+ and CD8+ T cells, and enhancement of tumor control in mice [48]. This evidence concerns the gene CD4 and neoplasm.