TB patients exhibited lower PSI values of both S100 Calcium Binding Protein A8 (S100A8)-intron1-retention intron (delta PSI (ΔPSI) = −0.14, P = 0.031) and Ribosomal Protein S20 (RPS20)-exon1-AP (ΔPSI = −0.56, P = 0.022) than HCs. This evidence concerns the gene S100A8 and tuberculosis.