AS is one of the major approaches that hosts and pathogens remodel the transcriptome.12,13 In TB, many studies reported the roles of AS events (RAB8B splicing, IL-12Rβ1 splicing, etc.)in the mycobacterium tuberculosis (MTB)-host interactions,14–18 highlighting the importance of AS in TB development. The gene discussed is IL12RB1; the disease is tuberculosis.