Conversely, in both priPC-1 primary cancer cells and established PANC-1 cells, shRNA-mediated knockdown or CRISPR/Cas9-induced knockout of MXRA5 exerted opposite functions by upregulating E-Cadherin, but downregulating N-Cadherin and vimentin (Fig. 5E). Here, MXRA5 is linked to cancer.