We observed B and T-cell receptors, chemokine, C-type lectin receptor, cytosolic DNA-sensing, HIF-1, IL-17, JAK-STAT, MAPK, metabolic, NF-kappa B, NOD-like receptor, PD-L1 expression and PD-1 checkpoint in cancer, RIG-I-like receptor, th1-th2 cell differentiation, th17 cell differentiation, thyroid hormone, TNF, and toll-like receptor signaling pathways in the KEGG pathways at FDR < 0.05 using STRING PPI networks (Supplementary Data 15, Supplementary Fig. 6). The gene discussed is CLEC4D; the disease is cancer.