MLKL and ischemic stroke: Knockout of receptor-interacting serine/threonine protein kinase 3 (RIPK3) or mixed-lineage kinase domain-like protein (MLKL), the key regulators of the necroptotic pathway, can reduce the severity of renal ischemia‒reperfusion (I/R) injury [4, 5] and ischemic stroke [6].