RIPK3 and alkaline phosphatase measurement: We detected the expression of p-RIPK3 and p-MLKL by immunofluorescence (Fig. 1A and Supplementary Fig. 1A), immunohistochemistry (Fig. 1B and Supplementary Fig. 1B), and western blot (Fig. 1C and Supplementary Fig. 1C, D) in the pancreas from mice with AP induced by cerulein plus LPS [32, 33].