RIPK3 and alkaline phosphatase measurement: The results showed that the pancreatic pathological scores (Supplementary Fig. 6A) and the abundance of macrophages (Supplementary Fig. 6B–F) of AP induced by cerulein alone were lower than those induced by cerulein plus LPS (Figs. 2A and 4A–C), and knockout of Mlkl or Ripk3 did not attenuate AP (Supplementary Fig. 6A), consistent with what was observed by Boonchan [25].